Ibland snubblar man över artiklar som är riktigt bra. Jag hittade denna idag:
https://www.ncbi.nlm.nih.gov/pubmed/28137612

Den är en översiktsartikel kring olika fastescheman och dess påverkan på det åldrande immunförsvaret och autoimmuna sjukdomar. Förvånansvärt stor del i artikeln avhandlar MS vilket är positivt.

En av författarna är Valter Longo som jag och andra länkat till tidigare i tråden. Min vana trogen citerar jag fritt från artikeln:

“After chronic Calorie Restriction (CR), 33% or 40% of mice showed a minor decrease in the EAE induction and disease severity but were protected from EAE induced inflammation, demyelination, and axon injury. Interestingly, only severe CR (66% caloric restricted group) completely prevented EAE induction. Similarly, a chronic ketogenic diet, consisting of a 4:1 ratio of fat to carbohydrate and protein, has been reported to serve as a preventive measure against EAE. However, similar to the effect of chronic moderate Calorie Restriction, Ketogenic Diet did not completely prevent the EAE disease induction but reduced the severity of the disease. Intermittent fasting (IF), where fasting is applied every other day, was also shown to improve EAE disease severity. Eight weeks of IF prior to the EAE immunization completely protected mice from EAE induction compared to 75% incident rate of ad libitum group.”

“Fasing Mimicking Diet (FMD) cycles not only resulted in a reduction in dendritic cells which are known to play an important role as antigen presenting cells (APC) that secrete cytokines responsible for activating T lymphocytes, but also reduced circulating MOG35–55 specific CD4+ T cells, Th1 and Th17 cells and reduced serum cytokines such as IFN-γ, IL-17 and TNF-α. Furthermore, the FMD treatment increased anti-inflammatory CD4+ Treg.”

“More importantly, the FMD treatments promoted oligodendrocyte precursor cell dependent regeneration of oligodendrocyte, which is known to participate in remylelination of demyelinated axons.”

“CR or various other dietary restrictions and particularly relatively long-term fasting, and FMDs cycles followed by re-feeding appear to decrease the biological rate of aging and promote anti-inflammatory effects, and may contribute to alleviate and possibly reverse a variety of autoimmune disorders as well as immunosenescence by killing old and damaged cells and replacing them with young and functional ones. However, the limited number of studies and of participants in studies described in this review, underlines the need for a set of larger randomized clinical trials testing both the feasibility and efficacy of FMDs, fasting and other DR-based interventions on the treatment of autoimmunities.”